FERTILITY DRUG – FEMARA (LETROZOLE) After three tries we Clomid, we could see that this medication was not working for us.  Unfortunately, Clomid wasn’t making the follicles that were produced grow and it was, instead of thickening, thinning out the lining of her uterus.  Why is this important?  The lining of the uterus must thicken between 10-12 mm in order to support the developing egg.  After an egg is implanted, the uterus continues to thicken naturally.  But getting the egg to implant in the uterus is the important first step.  A fertilized egg will not implant properly if the uterus is not thick enough. Keep in mind that most doctors recommend that you try a particular fertility drug for at least six cycles before giving up and moving on to another drug.  But remember, that is only a recommendation.  As a patient, you can take control of these decisions and decide to do something different.  It’s your budget, it’s your body and it’s your decision.  Just make sure you remember to communicate your concerns with your doctor openly and honestly and he or she shouldn’t have a problem with you if you decide to move on to try another fertility drug. Please remember, that when take fertility medication you do run the risk of having multiple births. So we did a little research, talked to some other women on various blogs and decided to try a drug call Femara (Letrozole).  Now Femara wasn’t originally intended for use as a Fertility Drug.  It is still actually used for the treatment of breast cancer.  But one of the side effects, if you can all it that, was that it caused a woman to have an increase in follicle production if taken day 3-8 or her menstrual cycle.  It is very important that Femera only be taken during those particular days because if taken while pregnant, it can cause abnormalities in a developing fetus.  Femara is excreted (has a half life)  by the liver after 72 hours, so it will be well out of your body by the time your doctor performs insemination on day 16-18 of your cycle. Again, it’s important to note, that this particular medication will not work for everyone.  Every woman’ body is different and responds differently to different medications.  Be sure to discuss with your doctor your particular options. In our case the Femara was working.  Not only did she produce 8 follicles.  At least two of those follicles grew to 18-20mm by day 18 or her cycle.  So we were ready for insemination.  This was our first try with insemination, on Femera, after going three cycles with Clomid, and not being able to get the follicles to grow properly. After the Femera has gotten the follicles to grow, we could have waited until my partner ovulated naturally, but we decided to help her ovulation along.  Our Fertility doctor gave her an HCG (Human chorionic gonadotropin) shot, which stimulates the release of an egg during ovulation.  We were then told to be back the next morning for insemination.  The clinic would thaw our sperm sample and would be ready for us in the morning. We did come back the following morning, when we had the IUI (Intrauterine Insemination) which took about five minutes.  My partner was told to lie on her back for an additional 10 minutes, after than she could resume normal activities.   Now we wait!


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